ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling
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چکیده
منابع مشابه
Identifying Targets of FTZ and FTZ-F1
Homeobox (Hox) proteins regulate cell fate and segmental identity throughout the animal kingdom. Yet, given the homeodomain's promiscuous DNA binding activity in vitro, it is unclear how they select downstream target genes. The product of fushi tarzu (ftz) is a Hox protein responsible for the development of alternate parasegments within the Drosophila embryo. It has been shown that FTZ interact...
متن کاملFtz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene.
The fushi tarazu pair-rule gene is required for the formation of alternating parasegmental boundaries in the Drosophila embryo. fushi tarazu encodes a homeodomain protein necessary for transcription of the engrailed gene in even-numbered parasegments. Here we report that, within an engrailed enhancer, adjacent and conserved binding sites for the Fushi tarazu protein and a cofactor are each nece...
متن کاملActivation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers
The orphan nuclear receptor Ftz-F1 is expressed in all somatic nuclei in Drosophila embryos, but mutations result in a pair-rule phenotype. This was explained by the interaction of Ftz-F1 with the homeodomain protein Ftz that is expressed in stripes in the primordia of segments missing in either ftz-f1 or ftz mutants. Ftz-F1 and Ftz were shown to physically interact and coordinately activate th...
متن کاملCell-Autonomous Requirement of the USP/EcR-B Ecdysone Receptor for Mushroom Body Neuronal Remodeling in Drosophila
Neuronal process remodeling occurs widely in the construction of both invertebrate and vertebrate nervous systems. During Drosophila metamorphosis, gamma neurons of the mushroom bodies (MBs), the center for olfactory learning in insects, undergo pruning of larval-specific dendrites and axons followed by outgrowth of adult-specific processes. To elucidate the underlying molecular mechanisms, we ...
متن کاملDrosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis.
During the metamorphic reorganization of the insect central nervous system, the steroid hormone 20-hydroxyecdysone induces a wide spectrum of cellular responses including neuronal proliferation, maturation, cell death and the remodeling of larval neurons into their adult forms. In Drosophila, expression of specific ecdysone receptor (EcR) isoforms has been correlated with particular responses, ...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2010
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2700